Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 343
    Published on July 31, 2018


High protein diet may cause heart failure in middle-aged men

Earlier studies show.

  • Amino acid (that make up the protein in our body) supplements will protect the heart health of some patients.
  • An enhanced risk to type 2 diabetes and cardiovascular mortality (or death) with the regular consumption of high protein diet, particularly protein from animals.
  • Negative effects on the gut health with low-carbohydrate and high protein diet.
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But there are no studies to find out an association between risk of heart failure and excess protein consumption.


The American Heart Association says 20 percent of the Americans aged 40 years and older are at risk of heart failure. There is no cure or treatment for heart failure condition and this condition reduces the life expectancy of a person. A person can prevent the heart failure event by eating the healthy diet and following a good lifestyle. A person can prevent heart failure events with the following measures.

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To reduce the heart disease risks, the American Heart Association says a person should eat following food items.

  • Whole grains such as whole wheat, oats, rye, whole-grain barley, brown rice etc.
  • Nuts.
  • Fish.
  • Poultry.
  • Milk and milk products containing low-fat.
  • Beans.
  • Fruits and vegetables.
  • Pulses.
  • Nontropical vegetable oils.
  • Limit the consumption of the following items.
    1. Red meat.
    2. Sweets.
    3. Sugary drinks such as carbonated drinks, energy drinks etc.
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A recent study has found an increased risk of fatal heart failure (HF) and reduced life expectancy with a high protein diet such as keto or Atkin's diet. Atkin's diet is a low carbohydrate diet and Ketogenic (or keto) diet is a high fat, adequate-protein, and low-carb diet. But these diets often lead to the consumption of high amounts of protein. Researchers say middle-aged people should eat food rich with vegetables and whole grains instead of eating high protein foods such as bacon and hamburger.

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Researchers say their study is the first study to find an association between risk of heart failure and a diet containing excess protein. The United States government says an individual should consume about 0.8 grams of protein per day per kilogram of body weight.

Researchers have conducted analytical and a 22.2-year follow-up study on 2,441 Finish middle-aged men, aged between 42 and 60 years. Researchers have used the Kuopio Ischaemic Heart Disease Risk Factor Study data. The participants were divided into four groups based on the quantity and the type of protein consumption. They calculated the risk of heart failure with the protein consumption using Cox proportional hazard ratios.

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The follow-up study shows the number of heart failure events diagnosed is 334. When they analyzed their protein consumption, 70 percent of the heart failure people are consuming excess protein from animal sources and 27.7 percent of them from plant sources. The following table shows the quantum of enhanced risk of heart failure in a person with a specific type of high protein consumption.

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Type of protein consumption * The risk of heart failure in %
Protein from all sources 33%
Dairy protein 49%
Animal protein 43%
Plant protein 17%
Fish and eggs 0%
* The enhanced risk is calculated by comparing
with the people who ate the least amount of protein.

Researchers say there are no earlier studies to find out this association and their study finding will apply to other populations including women. More studies are required to find out the heart failure risks with the diet and this study should be validated with another study. They say that it is premature to advocate limiting protein consumption to prevent heart failure events.

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Researchers say how the food has been prepared may play a role in increasing heart failure risks. They think that the increased heart failure risks are due to some amino acids. There is also a need to conduct a study to know the heart health benefits of the moderate quantity of protein consumption.

This study is not showing the cause-and-effect relationship between high protein consumption and heart failure. The study results did not include heart failure risks in women with high protein consumption.


Increased risk of fatal heart failure and reduced life expectancy with a high protein diet.
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The author of the study was Professor Jyrki Virtanen, Ph.D., nutritional epidemiology, the University of Eastern Finland, Kuopio, Finland. The study findings were published May 29, 2018 in the journal Circulation: Heart Failure. Title of the article was "Intake of Different Dietary Proteins and Risk of Heart Failure in Men. The Kuopio Ischaemic Heart Disease Risk Factor Study." DOI: doi.org/10.1161/CIRCHEARTFAILURE.117.004531


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