Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 325
    Published on April 19, 2018

 

Recategorization Of Diabetes Into Five Clusters For A Precise Diagnosis Of Diabetes And For An Individualized Treatment

Ads

With the current diabetes classification and guidelines, a healthcare professional can not predict precisely which patient requires an intensive diabetes treatment and how to control the high blood sugar (glucose) levels in a newly diagnosed patient with diabetes. Currently, diabetes is categorized as.


  • Type 1 diabetes: This is an autoimmune disease. This type of diabetes is caused due to the destruction of the insulin-producing beta cells by the immunity of the patient.
  • Type 2 diabetes: This type of diabetes is caused due to the increase in the blood sugar (glucose) levels as the cells can not absorb the glucose present in the blood due to the development of insulin resistance in the body.
  • Latent autoimmune diabetes in adults (LADA) (called as type 1.5 diabetes).
  • Maturity-onset diabetes in the young (MODY): This type of diabetes is caused due to the defects in the insulin secretion in the pancreas. This occurs in people aged less than 25 years.
  • Secondary diabetes: This diabetes is caused due to the destruction of the beta cells in the pancreas and/or acquired diseases cause the development of insulin resistance.

Ads Dietrine weight loss program helps you to losing weight and to reduce carbs, carbohydrates, and calories
See More Ads For "Body Weight Loss"


Recategorization of diabetes into SAID, SIDD, SIRD, MOD and MARD for an early treatment of diabetes.

In a study to find out the precise diagnosis of diabetes and individualized treatment of diabetes, researchers from Sweden and Finland led by the experts from the Lund University, Lund, Scania, Sweden have suggested the recategorization of diabetes.


A study on 13,270 newly diagnosed patients with diabetes, aged between 18 and 97 years, suggests the recategorization of diabetes based on physiological and genetic profiles to three severe diabetes clusters and two mild diabetes clusters. They also studied the development of diabetes and available treatment options to newly diagnosed patients. One of the new clusters is similar to type 1 diabetes and the other four clusters are subtypes of type 2 diabetes. Researchers isolated the following parameters during the study.


Ads This can burn 348% more fat and calories
See More Ads For "Lowering Body Fat"

  • Insulin resistance: A condition in which insulin calls (call to the transfer of energy and oxygen from the blood to cells) are rejected by the body cells.
  • Insulin secretion: Amount of insulin produced by the beta cells in the pancreas.
  • Blood sugar levels: Amount of sugar (glucose) produced by the liver from the food we eat.
  • The onset of diabetes.
  • Age.

Researchers have observed following during the study.

Cluster 1 - Severe autoimmune diabetes (SAID)

  • Patients are found to be with the highest levels of HbA1c (sugar or glucose levels in the blood) in the blood.
  • About 31 percent of likely risk of ketoacidosis at diagnosis compared to patients in cluster 3, 4 and 5.
  • About 42 percent of the patients are using insulin.
  • The lowest number of patients are using metformin.

Ads Naturally reversing diabetes derived from the bible
See More Ads For "Reversal Of Diabetes"

Cluster 2 - Severe insulin-deficient diabetes (SIDD)

  • Use of insulin is less than four percent.
  • The lowest number of patients are using metformin.
  • Patients in this cluster are at the highest risk of diabetic nephropathy and chronic diseases.
  • Patients are with a modest increase in the urinary albumin (a risk factor to kidney disease). People in this cluster are at a higher risk of end-stage renal disease.

Cluster 3 - Severe insulin resistant diabetes (SIRD)

  • Use of insulin is less than four percent.
  • The lowest number of patients are using metformin.
  • Patients in this cluster are at the highest risk of diabetic nephropathy and chronic diseases.
  • Patients are with a modest increase in the urinary albumin (a risk factor to kidney disease). People in this cluster are at a higher risk of end-stage renal disease.

Ads The proven 3-point method to melt away ugly body fat in just 15 minutes a day
See More Ads For "Lowering Body Fat"

Cluster 4 - Mild obesity-related diabetes (MOD)

  • Use of insulin is less than four percent.

Cluster 5 - Mild age-related diabetes (MARD)

  • Use of insulin is less than four percent.

In the new diabetes classification, researchers have proposed the following clusters for a precise diagnosis and an individualized treatment of diabetes.

Cluster 1 - Severe autoimmune diabetes (SAID)

  • An autoimmune condition, where the beta cells in the pancreas could not produce sufficient insulin to maintain the sugar (glucose) levels in the blood.
  • Presence of glutamic acid decarboxylase (GAD) antibodies in the blood.
  • Diabetes with the highest levels of HbA1c (sugar or glucose levels in the blood).
  • Corresponds to type 1 diabetes and latent autoimmune diabetes of adults LADA (called as type 1.5 diabetes).
  • Affected people are relatively low in body mass index (BMI) with a poor metabolic control.
  • Affect people are at a young age.

Ads Use this simple trick to melt over 40 pounds of belly fat
See More Ads For "Lowering Body Fat"

Cluster 2 - Severe insulin-deficient diabetes (SIDD)

  • Patients in this cluster are similar to Cluster 1 (severe autoimmune diabetes SAID), but without the glutamic acid decarboxylase (GAD) antibodies in the blood.
  • Diabetes arises as the beta cells in the pancreas fails to produce sufficient insulin.
  • Diabetes with the highest levels of HbA1c (or blood sugar or glucose levels).
  • The highest incidence of retinopathy.

Cluster 3 - Severe-insulin resistant diabetes (SIRD)

  • Patients in this cluster are with a higher body mass index (BMI).
  • Beta cells in the pancreas produce sufficient insulin that is required to transfer the glucose and oxygen from the blood to cells. But cells are not responding to insulin calls (a condition known as insulin resistance) to absorb glucose.
  • These people are at higher risk to diabetic nephropathy (kidney damage due to diabetes).

Ads This strategy reverses type 2 diabetes in 28 days. 100% Guaranteed!
See More Ads For "Reversal Of Diabetes"

Cluster 4 - Mild obesity-related diabetes (MOD)

  • Patients in this cluster are obese.
  • Younger in age.
  • No insulin resistance.

Cluster 5 - Mild age-related diabetes (MARD)

  • Occurs in the elderly people.
  • Diabetes development due to small metabolic changes.

Researchers say that the recategorization of diabetes can help healthcare professionals in making a better prediction of the risk associated with diabetes in a patient. The recategorization of diabetes can also help healthcare professionals in providing personalized and early treatment. Lead author of the study says that they found an evidence which shows the life-threatening complications associated with diabetes can be prevented with an early treatment of diabetes.


Ads No-nonsense method to lose 40 pounds a month
See More Ads For "Body Weight Loss"

Lead author of the study was Professor Leif Groop, MD, Ph.D., Lund University - Diabetes Center, Malmoe, Sweden. The study was published online March 1, 2018, in The Lancet Diabetes and Endocrinology. Title of the article was "Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables." DOI: doi.org/10.1016/S2213-8587(18)30051-2



Ads Green Coffee Bean Max contains antioxidants and chlorogenic acid from losing weight and to prevent obesity
See More Ads For "Body Weight Loss"



social:

        Twitter
If you like this article, please share it with a friend! Article address is (copy and paste the code below) :

Articles similar to this topic


Ads A simple diabetic nerve pain treatment program
See More Ads For "Cure To Diabetic Pain"

1. Common causes of death in patients with both type 2 diabetes and atherosclerotic cardiovascular diseases (ASCVD)
2. The number of complications that may be developed in patients with type 2 diabetes is not linked with diabetes severity.
3. Muscle cramp events and its frequency and its severity were linked to nerve function in type 1 diabetes, but not type 2 diabetes
4. A new vaccine developed by Scandinavian researchers could prevent type 1 diabetes
5. Ozempic (semaglutide) GLP-1 type 2 diabetes drugs from Novo Nordisk can reduce obesity and body fat levels
6. Patients with type 2 diabetes with chronic kidney diseases can survive longer with metformin
7. Lower risk to obesity and type 2 diabetes with the consumption of whole grains and milled whole grains

Ads Quickly burn off stubborn belly fat. Men and women. Any age.
See More Ads For "Lowering Body Fat"

8. Obesity, poverty are the factors for higher type 2 diabetes risk for American Blacks
9. Diet with high magnesium content can prevent type 2 diabetes
10. Higher urea levels or reduced kidney functionality can increase diabetes risk
11. Higher risk to hospitalization or premature death among heart failure patients with diabetes.
12. Researchers identified a link between obesity and type 2 diabetes
13. Longer breastfeeding decreases type 2 diabetes risk for mothers
14. Insulin pills may delay the onset of type 1 diabetes in some individuals
15. Patients with type 2 diabetes protections with antioxidant foods containing Vitamin C & E, lycopene or flavonoids
16. TRAFFIC, a Retrievable and Scalable Cell Encapsulation Device for the treatment of type 1 diabetes

Ads Human growth hormones (HGH) for physical stamina, lean muscle and weight loss
See More Ads For "Body Weight Loss"

 

Glutamic acid decarboxylase: Glutamic acid decarboxylase is an enzyme. Our pancreas will require this enzyme for the normal functioning of the pancreas. By mistake, our immune system makes antibodies to attack an enzyme called the glutamic acid decarboxylase. These antibodies are called Glutamic acid decarboxylase (GAD) antibodies. Studies show the presence of GAD antibodies in the blood of 70 percent of patients with type 1 diabetes.


Ads Reverse your type 2 diabetes in three weeks or less!
See More Ads For "Reversal Of Diabetes"

GAD: See Glutamic acid decarboxylase.

 

 

Sitemaps

Sitemap 1   Sitemap 2   Sitemap 3   Sitemap 4


The Diabetes News Chronicle does not provide medical advice, diagnosis or treatment. Information in Diabetes News Chronicle is to support and not to replace medical advice given by the surgeon or physician or doctor. The published article is not a medical advice by the OWNER of the "Diabetes News Chronicle" website or by the AUTHOR of the article.


Published by Jammi Vasista, Chennai, India.
Email Jammi[no-space]Vasista1991[at]gmail[dot]com
Phone 91-944-578-3182.
Address Diabetes News Chronicle, No 40, Kaveri Street, Rajaji Nagar, Villivakkam, Chennai, India. Pin : 600049.