Diabetes, Heart and Cardiovascular Diseases News Chronicle Diabetes, Cardiovascular and Heart Diseases. Article 323
Published on April 13, 2018 at 4:30 PM GMT


Scientists say CHIP is the new heart attack and stroke risk in healthy people


Risks such as plaque, atherosclerosis, cardiovascular, coronary heart disease, attack stroke with CHIP.

There are heart attack and stroke events in tens of thousands people without any heart disease risk factors such as high blood pressure or hypertension, high cholesterol, high blood sugar or glucose levels (type 2 diabetes T2D), smoking, heart diseases history and other risk factors. It is not known what causes these unexpected deaths from atherosclerosis or coronary heart diseases, (CHD) without any heart or cardiovascular diseases risk factor among healthy people.

Now, the scientists have accidentally found 40 to 50 percent enhanced death risks within 10 years from coronary heart disease or from any cause with an unusual accumulation of mutated stem cells in the bone marrow. Scientists were surprised with this phenomena and named this as Clonal Haematopoiesis of Indeterminate Potential (CHIP).

CHIP phenomena was known to other researchers previously while conducting research on other diseases. But they do not know that CHIP was linked to atherosclerotic cardiovascular disease (ASCVD).


The scientists says CHIP worsens health risks with age and increases heart attack and stroke risks substantially. About 20 percent of the individuals in their 60s and about 50 percent of the individuals in their 80s are being affected with CHIP. The heart disease risk associated with CHIP is equal to the risk associated with high blood pressure or high cholesterol levels. This condition is common and acts independently. Scientists says this discovery is a very important development in the field of cardiology.

This unusual accumulation of mutated stem cells in bone marrow is not an inherited but an acquired condition. CHIP may be caused due to the exposure to toxins such as cigarette smoke. Currently there are no medications or treatments to prevent this CHIP.

As cardiovascular diseases increases with aging process, CHIP explains why older or elder people are at higher risk to cardiovascular diseases, heart attack or stroke. But it is not known how mutated white blood cells causes cardiovascular diseases.

Heart disease risks with CHIP was first identified by Professor Benjamin Levine Ebert, MD, PhD, Professor of Medicine, Harvard Medical School (also Chair of Medical Oncology, Dana-Farber Cancer Institute ). With the help of Dr. Sekar Kathiresan, Professor Benjamin Levine Ebert confirmed that CHIP causes double risk to heart diseases in a typical patient and four fold enhanced risk to heart disease in younger people. Dr. Sekar Kathiresan, MD is a cardiologist at Cardiovascular Disease Prevention Center, Massachusetts General Hospital, Boston.


Professor Benjamin Levine Ebert and Dr. Kenneth B. Walsh have conducted experiments on mice models, which are prone to atherosclerosis development, by giving CHIP mutated stem cells along with non-mutated stem cells. Their experiments shows proliferation of mutated blood cells and enhanced inflammation causing more atherosclerosis in the arteries.

Earlier studies shows plaque formed in the arteries are filled with white blood cells causing inflammation. Researchers think atherosclerosis may be caused due to mutated white cells. Over a period of time, atherosclerotic plaque can rupture and stop energy and oxygen rich blood flow to heart and causes heart attack.

Scientists says there may be an association between CHIP with other inflammatory diseases such as arthritis, asthma, tuberculosis, periodontitis or sinusitis. But researchers says CHIP blood test, which costs about a few thousand dollars is not required as there is no drug or treatment to reduced the CHIP.

This study was funded by the National Institutes of Health, United States. The study findings were published in the New England Journal of Medicine. Title of the article was "Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease." DOI : dx.doi.org/10.1056/NEJMoa1701719


       
If you like this article, please share it with a friend! Article address is (copy and past the code below):

Also related to this story
1. A Breakthrough In Heart Failure Repair With Stem Cells
2. Air Pollution Due To Traffic May Lower HDL Cholesterol And Increase Risk To Cardiovascular Disease
3. AT04A vaccine reduces LDL cholesterol and atherosclerosis to prevent heart disease
4. A CT scan that can detect human coronary inflammation and helps us in gauging heart attack risk
5. Device To Find Out Internal Inflammation
6. DKK3 natural protein can protect against plaque formation, atherosclerosis, stroke and heart attack
7. Grey Hair Could Be A Sign Of Coronary Artery, Atherosclerosis And Heart Disease
8. Inflammation hormones risk with glucose-gobbling immune cells hidden in plaque of coronary artery disease CAD patients
9. Raspberries could lower inflammation, high blood sugar or glucose levels and improves insulin sensitivity
10. Reduced heart inflammation by eating brightly colored lutein carotenoid vegetables
11. Reduction in arterial fat and reversal of atherosclerosis with a trodusquemine drug
12. Risk Reduction To Inflammation Related Heart Diseases With Coffee Consumption
13. Stem cell from damaged heart tissue may worsen heart damage condition
14. Stem Cell Plaster Could Help Heart Failure Patients
15. Self-expanding (SE) stents outperform balloon-expandable (BE) stents for treating iliac artery (atherosclerosis) disease
16. Steps To Reduce Chronic Inflammation

 

Categories

Sitemap 1   Sitemap 2   Sitemap 3   Sitemap 4

 

Diabetes News Chronicle does not provide medical advice, diagnosis or treatment. Information in Diabetes News Chronicle is to support and not to replace medical advice given by surgeon or physician or doctor. Published article is not a medical advice by the OWNER of "Diabetes News Chronicle" website or by the AUTHOR of the article.


Published by Jammi Vasista, Chennai, India.
Email Jammi[no-space]Vasista1991[at]gmail[dot]com
Phone 91-944-578-3182.
Address Diabetes News Chronicle, No 40, Kaveri Street, Rajaji Nagar, Villivakkam, Chennai, India. Pin : 600049.