Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 320
    Published on April 6, 2018

 

High Levels Of Blood Urea Nitrogen (BUN) Can Increase The Risk Of Type 2 Diabetes

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An earlier study shows a two-way link between type 2 diabetes and kidney diseases. A current study at the Washington University School of Medicine, St Louis, Missouri, United States has found that the high blood urea nitrogen (BUN) levels can increase the risk of type 2 diabetes.



High blood urea nitrogen (BUN) levels can increase the risk of type 2 diabetes and high blood sugar (glucose).

The study has found that the risk of type 2 diabetes (high blood sugar levels) can increase with kidney dysfunction. The high levels of urea (a waste product of the kidneys) are the reason for the two-way link between type 2 diabetes and kidney diseases. This is the first study that shows that the BUN is an independent risk factor for type 2 diabetes.


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An analytical study over a period of five years on 1.3 million veterans without type 2 diabetes shows about nine percent of the people have higher levels of urea. The higher levels of urea may indicate a lower kidney function. The percent of people with a higher level of urea in the study is equal to the percent of the patients with kidney diseases in the general population.

The study has found 688 new patients with type 2 diabetes per 100,000 people every year with a higher level of urea (> 25 mg/dL). Kidney dysfunction can increase insulin resistance and impair the insulin secretion. The authors say that the risk of type 2 diabetes can be lowered by lowering the levels of urea.



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The senior author of the study was Dr. Ziyad Al-Al, MD, FASN, an assistant professor, Internal Medicine, Washington University School of Medicine, St Louis, Missouri, the United States. The study was published December 10, 2017, in the journal Kidney International. Title of the article was "Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus." DOI: doi.org/10.1016/j.kint.2017.08.033



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Urea: Urea nitrogen is a waste product of our body. This will be produced in our body during the breakdown of proteins (from our diet) and from our body metabolism.

Normally, urea from the blood will be separated and removed by the tiny tubules inside the kidney. Blood urea nitrogen (BUN) levels increases if the kidneys were unable to remove urea from the blood. High blood urea nitrogen (BUN) levels indicate kidneys are not functioning well.


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Increase in BUN levels may also due to the urinary tract obstruction, high protein diet, heart failure or dehydration. A damage or disease of the liver can also lower the BUN levels. The health of the Kidney can be improved by the following measures.

  • Eating a healthy diet.
  • Consuming more water.
  • Avoid smoking.
  • Regular exercise or workout.

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