Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 315
    Published on March 29, 2018

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Varenicline (Chantix), a common anti-smoking drug may increase cardiovascular disease risk

Varenicline (brand name Chantix) is an anti-smoking drug which helps smokers to quit the smoking habit. Earlier studies on the safety of varenicline were conflicting and they were conducted under highly controlled settings among individuals with similar features and backgrounds. An earlier study conducted under highly controlled settings shows usage of varenicline drug causes triple-risk to cardiovascular events.


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The risk of cardiovascular events increases when cells of the heart muscle do not receive sufficient oxygen and energy-rich blood. This event is caused due to narrowing of arteries (atherosclerosis disease) connected to the heart. The important cardiovascular events associated with insufficient blood supply to heart are

A current observational, population-based and self-controlled analytical study shows an increased risk to the development of cardiovascular events with the use of varenicline (brand name Chantix), an anti-smoking drug.

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The current study has been conducted among different people. They analyzed health records of 56,851 individuals taking varenicline drug between 2011 and 2015 in Ontario, Canada. They focused more in a year before and a year after the health of those individuals who took varenicline drug for 3 months (12 weeks).

The analytical study results show following observations.

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  • Emergency room (ER) visit or hospitalization events with heart problems in 4,185 individuals during the study period.
  • The study estimate shows 3.95 cardiovascular events per 1,000 individuals due to varenicline drug usage. This translates into 34 percent enhanced risk to emergency room (ER) visit or hospitalization events.
  • Among individuals with no heart problems prior to varenicline drug usage, varenicline anti-smoking drug usage has increased a cardiovascular event by just 12 percent.
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Researchers say that their study is not suggesting not to use varenicline drug to quit smoking. An individual should consider potential cardiovascular health risks and probable heart health benefits of varenicline drug usage. Researchers also say health care professionals should monitor the health of varenicline drug patient for the early detection of potential heart problems.

But this study is not showing cause and effect relationship and this study was not intended to find the mechanism behind the development of cardiovascular events with the use of varenicline anti-smoking drug.



Heart attack, stroke, irregular heartbeats arrhythmias, angina with Varenicline Chantix anti-smoking drug.
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Lead author of the study was Dr. Andrea S. Gershon, MD, a Fellow of the Royal College of Physicians of Canada (FRCPC) and an associate professor of medicine, University of Toronto, Canada. The study findings were published December 20, 2017, in the American Journal of Respiratory and Critical Care Medicine. Title of the article was "Cardiovascular and Neuropsychiatric Events Following Varenicline Use for Smoking Cessation." DOI : dx.doi.org/10.1164/rccm.201706-1204OC


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