Diabetes, Heart and Cardiovascular Diseases News Chronicle Diabetes, Cardiovascular and Heart Diseases. Article 312
Published on March 12, 2018 at 4:30 PM GMT

Study found diabetes and high body mass index association with greater cancer risks

Diabetes and obesity causes liver colorectal cancer in men and breast and endometrial cancer in women.

Earlier studies shows diabetes and higher body mass index (a risk factor to type 2 diabetes) are risk factors to multiple types of cancers such breast, colorectal, endometrial, gallbladder, liver and pancreatic cancers. But those studies did not show the number of new cancer cases due to diabetes or higher body mass index.

A comparative risk assessment study spanning 175 countries done during 2012 by the British researchers shows increased risk to the development multiple forms of cancer among people with diabetes and with body mass index (BMI) of more than 25kgs/meter2.

Researchers says the possible strong association between cancer and diabetes or high body mass index was due to biological mechanisms such as chronic inflammation, hyperglycemia (high blood sugar or glucose levels), hyperinsulinemia (excess levels of insulin in the blood) and the dysregulation of sex hormone activity. They also says factors such as insulin resistance and inflammation due to increased fat tissue may also increase cancer risks.

In a first documented study, researchers have analyzed the development of 12 types of cancers with diabetes or higher body mass index as risk factors. The study shows 792,000 or 5.6 percent of all cancer cases in the year 2012 are due to the combined effects of high body mass index (BMI) and diabetes.

For the study purpose, researchers have used GLOBOCAN data in estimating number of cancer cases and percentage of cases in each country and in each region. Study results shows

New cancer cases are expected to increase further due to lifestyle changes. Cancer cases in the coming years are expected to increase to more than 20 percent in men and to more than 30 percent in women. But these two risk factors are preventable with lifestyle changes.

Researchers says insulin may be a form of oncogenic viruses as earlier studies shows higher risk to colorectal and breast cancer with hyperinsulinemia. The cancer risk with insulin is irrespective of their body mass index (BMI). But the study could not show the cause and effect relationship between cancer and any risk factors.

Lead author of the the Wellcome Trust and NIHR funded study was Dr. Jonathan Pearson-Stuttard, Imperial College in London. The study findings were published November 28, 2017 in the The Lancet. Title of the article was "Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment." DOI : doi.org/10.1016/S2213-8587(17)30366-2

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Oncogene : Oncogene is a cancer causing DNA or RNA gene. Both DNA and RNA virus may cause tumours or tumors in animals. In humans, all DNA virus and a single RNA virus may cause cancer .



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