Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 293
    Published on January 20, 2018

Increased risk of type 2 diabetes and insulin resistance with psoriasis severity or higher body surface area (BSA)

Psoriasis is a common inflammatory dermatological or skin disease and a long-lasting autoimmune disease. About 2 to 4 percent of the adults were affected by psoriasis disease. Earlier studies show psoriasis association with the heart attack (the medical name is myocardial infarction), cardiovascular diseases, stroke, mortality, type 2 diabetes (T2D) and chronic inflammation.

A study by researchers at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, the United States show risk of the development of type 2 diabetes (T2D) among people with psoriasis and the quantum of type 2 diabetes (T2D) risk increases along with the severity of the psoriasis disease. This is the first study exploring the effects of type 2 diabetes (T2D) with the severity of psoriasis disease. This study has found a biological connection between type 2 diabetes (T2D) and psoriasis and also show psoriasis disease promotes insulin resistance.

Researchers have conducted studies with a group of 8,124 psoriasis individuals and another group of 76,599 individuals without psoriasis disease. They collected body surface area (BSA) of psoriasis patients, which indicates the severity of the psoriasis disease. They have done follow up studies for a period of four years. Follow up studies show new diabetes development in 280 (3.44 percent) individuals in psoriasis group and 1,867 (2.44 percent) individuals in the non-psoriasis group. After adjusting their findings with other risk factors to type 2 diabetes (T2D) such as the age of an individual, sex, obesity or body mass index (BMI) etc, researchers found

  • About 21 percent increased risk of development of type 2 diabetes (T2D) among the psoriasis-affected patients with BSA up to two percent compared to non-psoriasis individuals.
  • About 64 percent higher risk of the development of type 2 diabetes (T2D) among psoriasis-affected patients with BSA of ten percent or more compared to non-psoriasis individuals.
  • For every 10 percent increase in BSA, the risk of the development of type 2 diabetes (T2D) increases by 20 percent among psoriasis patients relatives to non-psoriasis patients.

The risk to type 2 diabetes insulin resistance with psoriasis severity or higher body surface area (BSA).

Researchers say healthcare professionals should provide special attention for the prevention of type 2 diabetes (T2D) among psoriasis patients with BSA more than 10 as they are at higher risk. Lead author of the study was Joel M. Gelfand, a professor of dermatology and epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, the United States. The study findings were published November 8, 2017, in the Journal of the American Academy of Dermatology. Title of the article was "Psoriasis and the Risk of Diabetes: A Prospective Population-Based Cohort Study."
DOI : doi.org/10.1016/j.jaad.2017.10.050

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