Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 281
    Published on December 29, 2017

Quick diagnosis of heart damage, heart attack or acute myocardial infarction (AMI) with new blood biomarker

Current ECG tests and other test procedures can easily diagnose major heart attacks (or acute myocardial infarction AMI). But smaller or minor heart attack events are common and diagnosing them is challenging.

Current test procedures involve checking for biomarkers including cardiac troponin from the blood sample to detect heart damage or risk of heart attack in individuals reported with chest pain. The test classifies an individual as low risk of heart attack if the cardiac troponin biomarker level is undetectable and the patient will be discharged from the hospital immediately. But up to 85 percent of the chest pain patients are being classified as an intermediate risk group, which requires overnight stay at the hospital, further observation and blood tests and increased medical costs.

Now, damage to the heart can be detected quickly or instantly within 20 minutes with a new test biomarker developed by the scientists at King's College London, United Kingdom (UK). The new test procedure checks cardiac myosin-binding protein C (cMyC) biomarker in the blood. Researchers found that this biomarker in the blood is more sensitive in detecting heart muscle damage as its level increases rapidly to higher levels compared to troponin biomarker. Quick diagnosis of heart muscle damage can be done with this new test. The current test procedure is failing in proper detection of the heart muscle damage. But this test enables proper detection of the heart attack. Patients without heart attack symptoms can be sent home quickly.

A study funded by the British Heart Foundation (a charity organization) has conducted tests to detect heart muscle damage with new test procedure among more than 2,000 people with acute chest pain in Europe. The new test found no heart attack incidents in a double number of patients compared to existing troponin biomarker test. Researchers say the new test procedure will be implemented on the NHS within five years.

Diagnosis of heart damage attack with myosin-binding protein C cMyC biomarker at the NHS United Kingdom.

One of the lead researchers of the study was Dr. Tom Kaier, BHF Clinical Research Fellow, King's College London. The study findings were published September 26, 2017, in the Circulation. Title of the article was "Direct Comparison of Cardiac Myosin-Binding Protein C With Cardiac Troponins for the Early Diagnosis of Acute Myocardial Infarction."

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Skipping breakfast can cause atherosclerotic plaques, cardiovascular and heart diseases

Spanish study results corroborate the significance of having breakfast for the health of the heart. This study shows a double risk of the development of atherosclerotic plaques and cardiovascular diseases among those individuals who skip breakfast or if the energy value of their breakfast (in calorie) is less than five percent of the recommended daily calorie consumption compared to those individuals who ate high energy breakfast.

Researchers in their studies analyzed 4,000 middle-aged individuals working in offices. Researchers monitored the events and the development of atherosclerotic plaques in them. Their routine breakfast calorie consumption was as follows.

  • 70 percent of the participants are under low-energy breakfast category, consuming between 5 and 20 percent of daily calorie requirement.
  • 20 percent of the participants are under high-energy breakfast category, consuming more than 20 percent of daily calorie requirement.
  • 7 percent of the participants had fruit juice, coffee or tea or skipped breakfast.
  • 3 percent of the participants are either had very little calorie breakfast or skipped breakfast.

Researchers used ultrasound technology to find out atherosclerotic plaques in all the participants. When compared with participants who are under high-energy breakfast category, the study findings show:

  • Those participants who used to skip breakfast regularly had 1.5 times more atherosclerotic plaques.
  • Those participants who used to skip breakfast regularly or eating very little had 2.5 times number of plaques in some part of the heart.
  • More chances of following unhealthy lifestyle habits among individuals who skip breakfast regularly.

Skipping breakfast can cause atherosclerotic plaques, cardiovascular and heart diseases.

Lead authors of the study were Irina Uzhova, a researcher from the Spanish National Center for Cardiovascular Research (CNIC), Department of Epidemiology, Atherothrombosis and Imaging (EAI), Madrid, Spain. The study findings were published October 2, 2017, in the Journal of American College of Cardiology (JACC). Title of the article was "The Importance of Breakfast in Atherosclerosis Disease: Insights From the PESA Study."

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