Study show duration of the psoriasis disease increases the risk of inflammation in blood vessels, cardiovascular diseases, heart attack and stroke
A study done by researchers suggests likely increased risk of heart attack and stroke in people living longer with psoriasis disease, which causes more systemic inflammation and intern causes more damage to vascular (a network of blood vessels) system. The psoriasis patient will be at higher risk of heart diseases and stroke even if the psoriasis patient does not have other risk factors such as tobacco usage, type 2 diabetes (high blood sugar levels) or old age.
Researchers have conducted imaging tests on 190 psoriasis patients and results show the intensity of the inflammation in the blood vessels is directly linked to the duration of the psoriasis disease in the patient. But imaging tests did not show an increased risk of heart attacks and stroke with vascular (a network of blood vessels) inflammation.
To find out the association, researchers examined about 87,000 Danish adults (average age being 54 years) with psoriasis disease (for over eight years) and another 4.2 million adult individuals without psoriasis disease. Researchers have done follow up studies for about five years. Study show 4,472 or 1.1 percent of adults with psoriasis disease had a major heart attack or stroke events every year compared to 152,122 or 0.8 percent of adults without psoriasis disease. Their study show one percent increase in the risk of heart attacks and strokes due to blood vessels inflammation among psoriasis disease patients.
Researchers hypothesized that chronic low-grade systemic inflammation (CLGSI) may be increasing risks to cardiovascular events. The inflammation associated with psoriasis is similar to the inflammation process in the body which play a part in atherosclerosis (hardening of the arteries) disease development. But the researchers could not factor the influence of obesity and exercise as those data are not available.
Lead authors of the study were Dr. Alexander Egeberg, Gentofte Hospital, Copenhagen, Denmark. The study findings were published August 18, 2017, in the Journal of the American Academy of Dermatology. Title of the article was "The relationship between duration of psoriasis, vascular inflammation, and cardiovascular events."
Psoriasis : Psoriasis is a chronic, inflammatory and lifelong skin disorder due to the formation of scales and itchy, dry patches on the surface of the skin. This disorder may also affect elbows, knees, scalp, joints, torso, palms, soles of the feet or nails. The disease affects both sexes, all ages and all races. This skin disorder may also cause pain and be swelling in the joints as it is associated with psoriatic arthritis. This disease worsens during colder winter months. But psoriasis is not a contagious disease.
Exact reasons for the disease development is not known but body immune system, environmental factors and genetic predisposition may be possible causes. Medical treatment intended to remove scales and to prevent the quick development of skin cells may help but the disease can not be cured completely. This disease comes and goes and comeback. Measures such as no tobacco usage, moisturizing skin and stress management may help.
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Published by Jammi Vasista, Chennai, India.