A multi-center study shows a non-surgical vessel-opening stent into narrowed and clogged artery due to plaque build-up (called as atherosclerosis disease) could be a better treatment option compared to medicines alone.
In a three years study, researchers followed 888 patients. Some of them are taking medications and others had undergone a non-surgical stent procedure (also known as percutaneous coronary intervention PCI or coronary angioplasty). Researchers found fewer urgent hospitalizations and less chest pain among those patients who had the stent early. Around 50 percent of the heart patients who are under medication alone had undergone emergency stenting finally.
Even though a heart patient had to spend a lot of money for stenting initially, the patient saves money subsequently due to reduced hospitalizations expenses and an urgent need for stenting procedures. The costs evened out after three years. This study shows there will be no increased cost after three years if a coronary artery disease (CAD) patient undergoes early stent operation.
Lead author of the study was Dr. William Fearon, Professor of Medicine (Cardiovascular Medicine), the Stanford University Medical Center. The study findings were published on November 2, 2017, in the Circulation. Title of the article was "Clinical Outcomes and Cost-Effectiveness of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease: Three-Year Follow-Up of the FAME 2 Trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation)."
Earlier studies show metabolic irregularities with a disturbance to circadian rhythms. A study done by researchers at the National Autonomous University of Mexico, Mexico City shows late night meals (meals after 8.00 pm) increases blood fat levels and increased risk of type 2 diabetes (T2D) and heart diseases apart from an increase in the waistline. The study also shows early meals will reduce blood fat levels. Researchers say an individual should avoid eating after 9.00 pm.
To know the changes to overall health with an out-of-sync lifestyle, researchers have conducted experiments with rat models by feeding snacks during their active phase and at the beginning of their rest period. Researchers have found higher fat levels (a risk factor for type 2 diabetes and heart diseases) in the blood with a meal at the beginning of their rest period. There was no variation in the fat levels in the blood when researchers removed part of the rat's brain which regulates 24-hour body activity cycle.
They say late night eating is against our a natural timing device (also known as a circadian clock or biological clock). The human body was synchronized with alternative duration of light and darkness. Nutrients in the bloodstream during night time will stick around our body for longer periods of time and finally absorbed by the fat tissues as our body was not ready for calories at night time. But changes in the lunchtime does not spike blood fat levels.
According to researchers, the health of an individual traveling through multiple time zones causes the least disturbance to the biological clock if the traveler performs daily routine activities according to home time zone.
Lead authors of the study were Dr. Ruud M. Buijs, PhD, a neurobiologist. The study findings were published November 7, 2017, in the Experimental Physiology. Title of the article was "The suprachiasmatic nucleus drives day-night variations in postprandial triglyceride uptake into skeletal muscle and brown adipose tissue."
Circadian rhythm : A 24-hour body activity cycle such as digestion.
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Published by Jammi Vasista, Chennai, India.