Diabetes, Heart and Cardiovascular Diseases News Chronicle Diabetes, Cardiovascular and Heart Diseases. Article 264
Published on October 29, 2017 at 10:30 AM GMT

Wearable and disposable paper-based device to measure sugar glucose levels from sweat to prevent hypoglycemia and seizure events

Device to measure sugar glucose from sweat to prevent hypoglycemia seizure during workouts exercise. Previous studies shows risk to cardiovascular diseases and high blood sugar glucose levels can be reduced in type 2 diabetes (T2D) patients with regular workout or exercise program along with diet containing low glycemic index foods and medications. Muscles and body cells consume more glucose sugar from blood while doing exercise. Risks to hypoglycemia or low blood sugar glucose levels exists for diabetic patients during exercise or workouts, which may lead to loss of consciousness and a seizure.

Researchers at the State University of New York, (Binghamton University or SUNY Binghamton) Binghamton have developed a new single use biosensor patch, which can help diabetic patients from hypoglycemia events while doing exercise or workouts. There are some flaws in the current devices using sweat to measure sugar glucose levels in an individual. They are

Researchers have eliminated all above flaws in this new wearable and disposable paper-based and plaster like device. The device measures sugar glucose levels using the sweat collected during the workout or immediately after the exercise, which is a non-invasive procedure. This device does not require external power supply and uses self-powered readout instruments. The investigator of this device was Assistant Professor Seokheun Choi, PhD Electrical and Computer Engineering, the Binghamton University, Binghamton, United States.

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Seizure : It is a serious medical condition associated with extremely low sugar (hypoglycemic or insulin shock) or high glucose levels in the blood, especially in an diabetic patient. This may not require emergency treatment. This may happen due to variations in the insulin levels, intercurrent disease (a disease during the course of another disease) or due to other metabolic factors.


Cortical bone microstructure and tibia density deficits may increase fracture risk in elderly or senior people with type 2 diabetes
Bone fracture in type 2 diabetes people with cortical compact microstructure tibia density deficits. Older (seniors) people with type 2 diabetes (T2D) succumb to fractures compared to older people without type 2 diabetes (T2D) even though older people with type 2 diabetes (T2D) have normal to higher bone density compared with people without type 2 diabetes (T2D). Bone fractures may lead to decreased quality of life, disability and even death with increased medical costs.

A study done by researchers shows bone density deficits in the distal tibia (image on right side) and cortical (or compact) bone microstructure are associated with increased HbA1c (or blood sugar glucose levels) in type 2 diabetes (T2D) patients. Researchers says traditional dual energy X-ray absorptiometry (also known as DEXA, DXA, bone density scan or bone densitometry scan) could not identify specific deficits in cortical (or compact) bone density in diabetic patients.

Researchers have conducted studies among 1000 women and men, with an average age of 65 years. They used high-resolution peripheral quantitative computed tomography (HRpQCT) to compare bone microarchitecture among healthy individuals and type 2 diabetes (T2D) patients. Results shows weakness in cortical bone microarchitecture (which can not be identified in standard bone density testing equipment) among older type 2 diabetes (T2D) patients. Researchers says fracture risks increases in type 2 diabetes (T2D) individuals due to the alterations in the microarchitecture of cortical (or compact) bone.

Lead author of the study was Elizabeth J. Samelson, PhD, the Hebrew SeniorLife's Institute for Aging Research, Boston, United States. The study findings were published on September 20, 2017 in the Journal of Bone and Mineral Research. Title of the article was "Diabetes and Deficits in Cortical Bone Density, Microarchitecture, and Bone Size: Framingham HR-pQCT Study."

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Bone : There are two types of bone tissues. They differ in their microstructure arrangement even though they are similar biologically (see the image above right).



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