Damage to the heart muscle due to coronary artery disease (CAD) causes heart failure. Quick help and medical treatment can minimize the damage to the heart muscle. Less damage to the heart muscle can improve the life expectancy of a heart patient. The heart attack patients can start their normal work between 14 and 90 days.
A study by Australian researchers at the Baker Heart & Diabetes Institute shows the prevention of the heart cell death following a heart attack with a single injection of HDL (GOOD) cholesterol. Researchers believe that the number of premature deaths due to heart failure caused by the heart attack can be reduced by treating them with high levels of HDL cholesterol.
Researchers have conducted a preclinical trial on mouse models. They treated them with a single injection of HDL (GOOD) cholesterol, immediately after a heart attack. This study demonstrated the prevention of death of the heart tissue and cells and improved heart function with a single injection of HDL (GOOD) cholesterol. Researchers say the muscle of the heart can absorb more glucose with a single injection of HDL cholesterol.
Lead researcher of the study was Professor Bronwyn Kingwell, BSc(Hons), Ph.D., an integrative physiologist, and NHMRC Senior Principal Research Fellow, Baker Heart & Diabetes Institute, Australia.
A heart attack is caused due to the high levels of cholesterol and hypertension (or high blood pressure. BP). Some part of the heart tissue will be replaced with a dead tissue with scars made of cells even if an individual survives a heart attack. These dead tissues with scars do not help the heart in pumping blood and may weaken the function of the heart.
The objective of this study was to restore the function of the heart by reprogramming scar tissue of the heart into the cardiac muscle cells (myocardiocytes, cardiomyocytes, or cardiac myocytes), which make up the heart muscle. They found that the GATA4 transcription factor protein can prevent the damage to the heart cells and tissue and weakening of the heart function.
In experiments with small animal models with a heart attack, a cocktail of Mef2c, GATA4 and Tbx5 (GMT) transcription factor protein treatments can lead to less scar tissue in the heart muscle and up to 50 percent improvement in heart function.
Author of the study was Dr. Megumi Mathison, MD, Ph.D., Associate Professor of Surgery, Baylor College of Medicine, Houston, Texas. The study was published on August 15, 2017, in the Journal of Thoracic and Cardiovascular Surgery. Title of the article was "Cardiac reprogramming factor Gata4 reduces postinfarct cardiac fibrosis through direct repression of the profibrotic mediator snail."
Transcription factor : A transcription factor (TF) is important for the normal development of the organism, in response to diseases and cellular functions. Gene's activity is controlled by a transcription factor (TF) (sequence-specific DNA-binding transcription factors). They bind to specific sites and determine whether DNA (deoxyribonucleic acid) of the gene can be copied into RNA (ribonucleic acid). The rate of transcription of genetic information to RNA from DNA will be controlled by transcription factor (TF). RNA (Ribonucleic acid) molecule play multiple biological roles. Efficiency and functionality of the RNA (Ribonucleic acid) molecule will be controlled by transcription factor (TF). A paper published in 2002 has estimated the number of transcription factors (TF) between 2000 and 3000 in the human body.
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Published by Jammi Vasista, Chennai, India.