Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 230
    Published on August 21, 2017

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A link between depression and swings in blood sugar levels among patients with type 2 diabetes

A study on elder people with type 2 diabetes (T2D) by the Israeli researchers at the Sheba Medical Center, Ramat Gan, Israel, shows an association between depression symptoms (and also cognitive decline) and fluctuations in long-term HbA1c levels. Researchers studied 837 type 2 diabetes (T2D) individuals with an average age of 73 years. The study shows 29 percent increase in depression symptoms with every one percent variation in HbA1c levels.


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Researchers say their study results suggest importance in maintaining glycemic control in preventing depression symptoms in older patients with diabetes. The researchers say their study is not showing the development of depression with the fluctuations in HbA1c levels (or blood glucose or sugar levels). The study just shows a link between the two conditions. But the risk of depression among older diabetic individuals can be reduced with better control of blood sugar or glucose levels.


A link between depression and swings in blood sugar levels among patients type 2 diabetes.
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Lead author of the study was Dr. Ramit Ravona-Springer, MD, Joseph Sagol Neuroscience Center (JSNC), Sheba Medical Center, Ramat Gan, Israel. The study findings were published on July 19, 2017, in the Diabetes Care. Title of the article was "Hemoglobin A1c Variability Predicts Symptoms of Depression in Elderly Individuals With Type 2 Diabetes."


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Enhanced risk of type 2 diabetes, cardiovascular disease (CVD) and overall mortality with an early menopause

A study by the researchers at the Erasmus University Medical Center, Rotterdam, the Netherlands shows increased chances to the development to type 2 diabetes (T2D) with an early or premature onset of menopause. Their study shows a four-fold increased risk of the development of type 2 diabetes (T2D) in women with menopause before the age of 40 years (a premature menopause) compared with those women who menopause after the age of 55 years (a late menopause). Researchers say the association between the development of type 2 diabetes (T2D) and premature menopause is independent of other risk factors such as genetic susceptibility or genetic predisposition and obesity or overweight or higher body mass index (BMI).


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The researchers have studied 3,639 postmenopausal women. They collected their natural menopause onset age, blood sugar or glucose levels and diabetes status. They categorized them into following groups as per the age of reaching menopause.

Age of reaching menopause Category name
Less than 40 years Premature
Between 40 and 44 years Early
Between 45 and 55 years Normal
More than 55 years Late menopause
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The researchers had done a ten-year follow-up study. Their follow-up studies show the development of type 2 diabetes (T2D) in 348 women. They found minimal differences in health biomarkers (such as hormone levels, obesity or overweight and genetic susceptibility or genetic predisposition) which contributes to the development of diabetes in with and without diabetes groups. This study suggested that an early menopause can be an independent marker for the type 2 diabetes (T2D) development and subsequent complications such as cardiovascular diseases, overall mortality and risk of future diseases.



Risk of type 2 diabetes cardiovascular disease CVD and overall mortality with an early menopause.
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Co-authors of the study were Dr. Eralda Asllanaj and Dr. Taulant Muka, from the Department of Epidemiology, Erasmus University Medical Centre (Erasmus MC), Rotterdam, Netherlands. The study findings were published 18 July 2017 in the journal Diabetologia. Title of the article was "Age at natural menopause and risk of type 2 diabetes:a prospective cohort study."


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