Diabetes, Heart and Cardiovascular Diseases News Chronicle. Diabetes, Cardiovascular and Heart Diseases. Article 227
Published on August 17, 2017 at 8:00 AM GMT


 



The intestinal virus could affect type 1 diabetes development in children

The intestinal virus could affect type 1 diabetes development in children.

A study done by researchers at the Washington University School of Medicine, St Louis, United States shows an increased risk for the development of type 1 diabetes (T1D) among children with an intestinal virus. The identified intestinal virus generates new antibodies among children with less diverse gut viral communities. The study also shows the less likely risk of the development of type 1 diabetes (T1D) among children who are carrying virus belonging to a circoviridae family in their intestine.



Researchers say they identified a virus group which is associated with risk reduction in the development of type 1 diabetes (T1D) in children and another virus group (produces antibodies that work against cells) which is associated with increased risk of the development of type 1 diabetes (T1D) in the children. Researchers think the balance of these two virus groups determine the development of antibodies that work against the cells in the body and lead to the development of type 1 diabetes (T1D) condition in the children. They also think circovirus is good for high-risk type 1 diabetes (T1D) individuals. Researchers say circoviruses virus can be used to prevent the development of type 1 diabetes (T1D) among children who are at high risk for type 1 diabetes (T1D).

Dr. Guoyan Zhao, PhD, Assistant Professor, Department of Pathology & Immunology, Washington University School of Medicine, was the first author of the study and lead author of the study was Dr. Herbert 'Skip' Virgin IV, MD, PhD, Department of Pathology & Immunology, Washington University School of Medicine. The study findings were published on July 25, 2017, in the journal Proceedings of the National Academy of Sciences (PNAS). Title of the article was "Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children".



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Higher risk of periodontitis or gum or tooth disease in type 2 diabetes (T2D)

Higher risk of periodontitis or gum or tooth disease in type 2 diabetes (T2D).

There are no studies establishing an association between type 2 diabetes (T2D) and the oral microbiome. An earlier report by the American Academy of Periodontology and the European Federation of Periodontology says there is no evidence which shows changes in the oral microbiome with type 2 diabetes (high sugar or glucose levels). A new study done by the researchers at the University of Pennsylvania shows the risk of the development of periodontitis condition with type 2 diabetes (T2D) and the significance of keeping healthy teeth among type 2 diabetes (T2D) patients.



Experiments with diabetic mice models by the researchers show the shifting of oral microbiome (with a less diverse community of bacteria) associated with bone loss and increased inflammation. Their study shows an increase in the levels of IL-17 or interleukin-17 protein and the development of periodontitis with type 2 diabetes (T2D) or hyperglycemia. Periodontal disease in humans is associated with increased levels of IL-17 or interleukin-17 protein.

The NHS, says periodontal condition causes gums to bleed, an unlikable taste, loss of teeth, bad breath and the formation of pus in gums or in the bones that hold teeth. Senior author of the study was Professor Dana T Graves, DDS, DMSc, Department of Periodontics, Penn Dental Medicine, the University of Pennsylvania.



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