Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 221
    Published on August 5, 2017

 

Reversal of type 2 diabetes, weight loss and reduction in muscle fat with a vegetarian diet

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A study on patients with type 2 diabetes shows a reduction in muscle fat and a double weight loss with a vegetarian diet compared with a low-calorie diet (a diabetic diet as per the recommendations of the European Association for the Study of Diabetes. EASD). A six-month study was on 74 patients with type 2 diabetes with either a vegetarian diet or with a low-calorie diet. The calorie intake in both the groups was reduced by 500 calories to the levels between 1,500 and 1,800 calories per day.



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Reversal of type 2 diabetes, weight loss and reduction in muscle fat with a vegetarian diet.

In the first three months or in the first half of the study, patients under the vegetarian diet had lost an average of 14 pounds and patients under the low-calorie diet had lost an average of seven pounds. In the second half of the study, the participants followed the similar diet but performed the aerobic exercises for an hour, three times a week. They gained muscle mass in that period and registered a little weight loss. Researchers studied the adipose (fat-storage) tissue of the participants that store fat with the help of magnetic resonance imaging. The study shows.

  • A similar loss of fat in the subcutaneous tissues in patients following both forms of diet.
  • A subfascial fat loss and the intramuscular fat loss was observed in patients following a vegetarian diet.
  • 42 percent of the patients with a vegetarian diet have reduced the treatments to lower blood sugar levels compared with five percent of the patients under the low-calorie diet.
  • A reversal of type 2 diabetes (T2D) was observed in three patients under the vegetarian diet.

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An earlier study shows a higher muscle fat is associated with a higher insulin resistance in patients with type 2 diabetes (T2D). Functioning of insulin in patients with type 2 diabetes improves as the muscle fat reduces. Authors say the vegetarian diet not only cause a weight loss but also address the cause of the type 2 diabetes. The following table shows the food items consumed in both types of diets.



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Vegetarian Diet Low-Calorie (Diabetic) Diet
Vegetables Colorful vegetables
Grains A quarter of lean protein
Legumes A quarter of starch
Fruits  
Nuts  
One serving of low-fat yogurt  

The lead author of the study was Dr. Hana Kahleova MD, Ph.D., director of Clinical Research, Physicians Committee, Washington DC, United States. The study was published in the Journal of the American College of Nutrition. Title of the article was "The Effect of a Vegetarian vs Conventional Hypocaloric Diabetic Diet on Thigh Adipose Tissue Distribution in Subjects with Type 2 Diabetes: A Randomized Study".



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A single dose of the glucagon-blocking drug (REMD-477) found to be effective in reducing insulin need

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A small study on 21 patients with type 1 diabetes (T1D) at the University of California, San Diego, United States shows improvement in the blood sugar (glucose) levels with a single dose of a human monoclonal antibody and an investigational glucagon-blocking drug called REMD-477. The study also shows a remarkable reduction in the insulin requirement in the patients. The study shows.



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  • More patients have achieved the target levels for blood sugar (glucose) with REMD-477, compared with placebo.
  • The insulin requirement was 26 percent less in patients with REMD-477 when compared to insulin requirement in patients with other treatments.

A single dose of the glucagon-blocking drug (REMD-477) found to be effective in reducing insulin need.

Lead author of the study was Jeremy Pettus, MD, assistant professor of medicine, endocrinology department, the University of California, San Diego, United States. The study was presented at the American Diabetes Association, 77th Scientific Sessions, San Diego Convention Center, United States. Title of the presentation was "Glucagon-Blocking Drug Reduces Need for Insulin and Improves Blood Glucose Levels for Patients with Type 1 Diabetes".



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