Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 219
    Published on July 30, 2017

 

The REMOVAL trial shows a lower risk of heart disease with metformin

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A study at the University of Glasgow, Scotland, shows a cut in the long-term risk of heart disease with metformin (a drug used for the treatment of diabetes) in the middle-aged patients with type 1 diabetes (T1D) who are with increased risk factors related to cardiovascular diseases (CVD). In the REMOVAL trial, researchers used an ultrasound to measure atherosclerosis in the carotid arteries (In the neck area. Supply blood to the neck, face and brain). The total number of adult participants in the REMOVAL trial was 428, aged 40 years or more with a long-standing type 1 diabetes. The participants in the trial had at least three of the following risk factors related to cardiovascular diseases (CVD).



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The REMOVAL trial shows a lower risk of heart disease with metformin.

In the REMOVAL trial, the participants were under either metformin or matching placebo medication. Researchers observed the following in the participants with the metformin.

  • Weight loss.
  • Reduction in the insulin doses.
  • Reduction in HbA1c levels (sugar levels, glycemic levels. GI) in the first three months of the study.
  • Reduction in cholesterol levels. More than 80 percent of the participants were taking statin therapy before the trial and further reduction with metformin was found during the REMOVAL trial.

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Researchers say the REMOVAL trial shows a lower risk of heart disease with a metformin in patients with type 1 diabetes (T1D). They also say the guidelines should be updated as the study shows metformin reduces blood sugar (glucose) levels for a very short period of time.

The chief investigator of the study was Professor John Petrie, MD, Ph.D., at the University of Glasgow, Scotland. The study was presented to the American Diabetes Association during 77th Scientific Sessions, San Diego Convention Center, United States. The study was published on June 11, 2017, in The Lancet Diabetes & Endocrinology. Title of the article was "Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomized, placebo-controlled trial".



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Preeclampsia (gestational hypertension) was linked to the increased risk of heart disease in the future in women

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The Heart Foundation, Australia says there is an enhanced risk of heart diseases in the future in those women who suffered from preeclampsia or gestational hypertension (High blood pressure. Pregnancy-induced hypertension. PIH) during pregnancy. Ms. Julie Anne Mitchell, the national spokeswoman for the women's heart health of The Heart Foundation, Australia says women who suffered from preeclampsia or gestational hypertension (High blood pressure. Pregnancy-induced hypertension. PIH) during pregnancy should monitor their heart health after pregnancy. They call the pregnancy an "ultimate cardiac stress test".


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Preeclampsia (High blood pressure. Pregnancy-induced hypertension. PIH) was linked to risk of heart disease in the future in women.

An Australian study on pregnant women shows the development of high blood pressure in around 30,000 women and preeclampsia in 10,000 women. Preeclampsia is a dangerous complication and forces the heart to work harder. An earlier study shows the following complications in the future with preeclampsia (gestational hypertension).


  • A four-fold enhanced risk of high blood pressure.
  • Two to three times enhanced risk of cardiovascular diseases.


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