Diabetes News Chronicle


Diabetes, Cardiovascular And Heart Diseases - 217

 

Published on July 27, 2017 at 01:00 PM GMT

BCG vaccine could restore proper immune response in type 1 diabetes

BCG vaccine could restore proper immune response in type 1 diabetes A new FDA-approved clinical trial done by the researchers at the Massachusetts General Hospital, United States shows restoration of immune response to produce insulin in mice models with advanced type 1 diabetes (T1D) with the genetic vaccine bacillus Calmette-Guerin (BCG). Researchers made this vaccine by using a harmless strain of bacteria which causes tuberculosis, which was approved earlier by United States FDA for the treatment of bladder cancer.

Type 1 diabetes (T1D) occurs due to the attack of T cells (Tregs) on the immune system. Researchers says genetic bacillus Calmette-Guerin (BCG) vaccine can restore permanent gene expression and restore T cells (Tregs). Researchers have completed successful type 1 diabetes (T1D) reversal trials with mice models. Subsequent human trials with BCG vaccine were successful and the study results were expected by the end of 2017.

Now the researchers are enrolling type 1 diabetes (T1D) patients for a five-year Phase II trial of BCG vaccine involving 150 adult individuals. They wanted to see the improvement or reversal of type 1 diabetes (T1D) with a repeated BCG vaccination. Principal investigator of the study was Dr Denise Faustman, PhD, Director, Immunology Laboratory, the Massachusetts General Hospital, Boston, United States. The study findings were presented at the 75th Scientific Sessions of the American Diabetes Association.

Articles related to   Vaccine

 

Excess weight may reduce early death risk for older adults with diabetes

Excess weight may reduce early death risk for older adults with diabetes A study done by the researchers at the Capital Medical University, Beijing, China shows risk reduction to early death by 18 percent and extend life span during later life with excess weight (obese or overweight or higher BMI) in older adults with diabetes. Earlier studies shows adverse health risks with obesity or overweight. But this study results shows benefits to older adults with diabetes during later life by holding some excess weight. Researchers came to this conclusion after analyzing 250,000 type 1 diabetes (T1D) or type 2 diabetes (T2D) patients from 20 studies.

In their studies, researchers assessed body mass index (BMI) of the participants and investigated the association of BMI with all-cause mortality risk. Researchers have done follow-up studies between 2.9 to 16.7 years. Their study results shows a lower risk of all cause mortality with body mass index (BMI) in the range of overweight or obese compared with individuals with normal body mass index (BMI).

Researchers unable to explain the link between longer lifespan for older adults with diabetes and overweight or obesity or higher BMI in later life. Earlier studies shows an inverse association between insulin resistance and muscle mass. Body weight reduces as lean muscle mass reduces with age. Reduction in bodyweight in older adults could lead to worse health outcomes. Co-author of the study was Yu Jie Zhou, from An Zhen Hospital, the Capital Medical University, Beijing, China. The study findings were published in the Journal of Diabetes Investigation, under the title "Impact of obesity on mortality in patients with diabetes: Meta-analysis of 20 studies including 250,016 patients".

Articles related to   Weight   |   Health Risks

 

 

Categories

Sitemap 1

Sitemap 2

Sitemap 3

Articles related to Acids Page 1  

Articles related to Approval Page 1  

Articles related to Apps Page 1   Page 2  

Articles related to Blood Sugar Levels Page 1  

Articles related to Blood-pressure Page 1  

Articles related to Cancer Page 1  

Articles related to Cardiovascular Diseases Page 1  

Articles related to Children Page 1  

Articles related to Cholesterol Page 1  

Articles related to Dementia Page 1  

Articles related to Dental Problems Page 1  

Articles related to Depression Page 1  

Articles related to Drugs Page 1   Page 2  

Articles related to Eldercare Page 1  

Articles related to Gut Microbiomes Page 1  

Articles related to Health Benefits Page 1   Page 2  

Articles related to Health Biomarkers Page 1  

Articles related to Health Risks Page 1   Page 2   Page 3   Page 4   Page 5  

Articles related to Health Supplements Page 1   Page 2  

Articles related to Heart Diseases Page 1   Page 2   Page 3  

Articles related to Hormones Page 1  

Articles related to Insulin Page 1   Page 2  

Articles related to Kidney Page 1  

Articles related to Liver Diseases Page 1  

Articles related to Metformin Page 1  

Articles related to Miscellaneous Page 1  

Articles related to Neuropathy Page 1  

Articles related to Obesity Page 1  

Articles related to Physical Activity Page 1  

Articles related to Pollution Page 1  

Articles related to Precautions Page 1  

Articles related to Retinopathy Page 1  

Articles related to Sleeping Disorders Page 1  

Articles related to Stroke Page 1  

Articles related to Therapy Page 1  

Articles related to Weight Loss Surgery Page 1  

Articles related to Women Health Page 1   Page 2  

 

Diabetes News Chronicle does not provide medical advice, diagnosis or treatment. Information in Diabetes News Chronicle is to support and not to replace medical advice given by surgeon or physician or doctor. Published article is not a medical advice by the OWNER of "Diabetes News Chronicle" website or by the AUTHOR of the article.


Published by Jammi Vasista, Chennai, India.
Email Jammi[no-space]Vasista1991[at]gmail[dot]com
Phone 91-944-578-3182.
Address Diabetes News Chronicle, No 40, Kaveri Street, Rajaji Nagar, Villivakkam, Chennai, India. Pin : 600049.