DELC Frank coronary artery|Apnoea apnea diabetes|Biopolymer

Diabetes, Cardiovascular And Heart Diseases - 210

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Published on July 5, 2017 at 03:00 PM GMT

OBSTRUCTIVE SLEEP APNOEA (OR APNEA) IS ASSOCIATED WITH DIABETES AND HIGH BLOOD PRESSURE (BP)
A study done by the researchers at Pennsylvania State University College of Medicine, United States shows four fold increase to high blood pressure (BP), a risk factor to heart attack with mild-to-moderate obstructive sleep apnoea (or apnea). Health specialists from the American Academy of Sleep Medicine, Westchester, Illinois, United States says mild-to-moderate obstructive sleep apnoea (or apnea) is associated with almost three times increased risk to diabetes compared with individuals without sleep apnoea (or apnea). They also says young and middle aged adults are strongly associated to risks with mild-to-moderate obstructive sleep apnoea (or apnea). Risks will be more

Among those individuals who are associated with sedentary behavior
Among those individuals who consume more salt
Older adult individual with age more than 65 years
Obese or over weight individuals

Researchers came to above conclusion after conducting analytical studies among 1,741 adult participants from the Penn State Adult Cohort. Yun Li, a researcher in the study, says young and middle aged adults suffering with obstructive sleep apnoea (or apnea) should take treatment to prevent heart attacks as the condition is a risk factor to increased high blood pressure (BP). Lead author of the study was Professor Alexandros N Vgontzas, Department of Psychiatry, the Pennsylvania State University College of Medicine and the study findings were published online in the journal Sleep.

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CONTROLLING WEEKS OF BLOOD SUGAR LEVELS WITH A NEW BIOPOLYMER INJECTION
Risk to serious complications increases to a diabetic patient unless the patient controls blood sugar levels within normal range. Even though, there are number of treatment options available for the patient including insulin, diabetes patient struggles to keep blood sugar levels within normal range. Researchers at the Duke University Graduate School, Durham, North Carolina, United States have invented an elastin-like polypeptide, a solution, which can replace daily or weekly insulin requirement of the body. This new drug can be injected once or twice per month. The drug can be injected with normal needle into the body.

A biodegradable gel will be formed in the body with the injected elastin-like polypeptide solution due to the body heat. Drug will be released slowly and steadily through this gel, without showing high and low levels of insulin, a trouble with other GLP1 drug delivery treatments. This biopolymer injection drug lasts three times longer compared with other form of drugs.

Researchers conducted successful tests with the rhesus monkey models and they are planning to conducts tests with other animal models. First author of the study was Kelli Luginbuhl, a student and the senior author of the study was Professor Ashutosh Chilkoti, Biomedical Engineering at the Duke University Graduate School. The study findings were published in the Nature Biomedical Engineering.

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DIAGONAL EARLOBE CREASE (DELC) OR FRANK'S SIGN COULD PREDICT RISK OF CORONARY ARTERY STENOSIS DISEASE
A creas or fold in the skin of the earlobe is called diagonal earlobe crease (DELC) or Frank's sign. A study done by Chinese researchers says risk to heart disease of an individual can be linked to the presence of diagonal earlobe creases (called DELCs) and this risk is independent of normal cardiac risk factors. Researchers found that adult individuals with just one creased earlobe are at higher risk to coronary artery stenosis compared with non-creased ears. Significant higher incidents of coronary artery stenosis among individuals with both ears having creased earlobe when compared with individuals with one creased earlobe or no creased earlobe. In medical terms, narrowing of a body channel is called stenosis.

Researchers followed more than 500 adult artery disease patients, aged between 36 and 91 and came to above conclusion. Bilateral diagonal earlobe crease (DELC) or Frank's sign are more common among

Male individuals
Old age individuals
Individuals suffering with severe coronary artery atherosclerosis

The current study shows coronary heart disease can be identified in a simple, possible and practical way with DELCs. But further research is required to uncover the association between DELCs coronary heart disease (CHD). Some researchers suggested that DELCs condition may be due to impaired circulation or due to genetics. The study findings were published in the BMJ.

Articles related to Sign | Health Risks | Coronary Artery

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