Diabetes, Heart and Cardiovascular Diseases News Chronicle. Diabetes, Cardiovascular and Heart Diseases. Article 189
Published on May 16, 2017 at 01:00 PM GMT


 



Obesity Increases Type 2 Diabetes Or Post Donation Diabetes Mellitus (PDDM) Risk Among Living Kidney Donors (LKD)

Obesity overweight higher BMI increases type 2 diabetes T2D risk among living kidney donors (LKD).

A study done by researchers shows higher risk of the new type 2 diabetes (T2D) development among living kidney donors (LKD) who are overweight or obese. The researchers studied pre-donation pharmacy fill records of 20,138 living kidney donors (LKD). The researchers checked insulin and non-insulin based diabetes medicines used by living kidney donors (LKD) individuals with pharmacy fill to find out new onset post-donation diabetes mellitus (PDDM).

The average age of living kidney donors (LKD) individuals is 42.7 years. 40.8 percent of the individuals were overweight (body mass index BMI between 25 to 30 kg/m2 ) and 22.8 percent of the individuals are obese (body mass index BMI more than 30 kg/m2 ). Medications to treat post-donation diabetes mellitus (PDDM) in living kidney donors (LKD) increased gradually. The study findings show



  • Five-year risk of post-donation diabetes mellitus (PDDM) medication treatments other than insulin increased in a graded manner as BMI increases. It is 0.6 percent in normal weight LKD individuals, 1.5 percent in overweight LKD individuals and 3.4 percent in obese LKD individuals
  • Five-year risk of diabetes was found to be 3.0 fold higher in overweight LKD individuals and 6.4 fold in obese LKD individuals compared with normal weight LKD individuals
  • Adjusted five-year risk of insulin usage was 5 fold higher in obese LKD individuals compared with normal weight LKD individuals

The above study findings show obesity is a risk factor for post-donation diabetes mellitus (PDDM) in living kidney donors (LKD) individuals. Author of the study is Professor Krista L Lentine, MD, PhD, at Saint Louis University (SLU), Saint Louis, Missouri and the study findings were presented at the 2017 American Transplant Congress, Chicago.



       
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A German Study Shows Zinc Supply Affects Heart Health

Low level of Zinc affects cardiovascular diseases, heart muscles, cardiac function and heart health.

A study done by German researchers at Technical University, Munich shows an increased risk of cardiovascular diseases and cardiac function due to oxidative stresses associated with low levels of zinc in the body. Earlier studies indicated increased cellular stress with very low levels of zinc. But chances of very low levels of zinc is very rare.



The researchers monitored vitamin E and glutathione antioxidants in the young piglets. Free radicals were disabled by vitamin E and glutathione antioxidants. The researchers conducted experiments by varying nutritional zinc levels in piglets for few days to find out how heart muscles are affected by declining amount of zinc. Results show as zinc levels in the body decline, levels of vitamin E and glutathione in the heart muscle too declined. The reduction in vitamin E and glutathione levels affected abilities of the heart in handling oxidative stress. The study findings were published in the journal Nutrition.



       
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Zinc : Zinc is a natural metal and body requires a small amount of this metal for multiple numbers of body functions and to activate body enzymes. Important functions of zinc in the body include healthy cell division, preventing free radicals, learning & memory function, wounds or ulcers healing, immunity improvement etc.

 



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