Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 84
    Published on November 23, 2016

Autoimmune Diseases Decreases With Physical Exercise

A number of diabetes patients do not exercise daily even though studies show exercise benefits diabetes patients and risks to autoimmune diseases decreases with exercise. Health guideline of UK and United States recommends 150 minutes of moderate physical activity or 75 minutes of vigorous physical activity per week. In a new in-depth study done on benefits of exercise by researchers from the University College London and the University of Cambridge shows exact health benefits with physical activity. The results are

  • As physical activity increases, health benefits increases
  • Health benefits are maximum if an individual exceeds 150 minutes of recommended weekly exercise
  • The risk of type 2 diabetes (T2D) reduces by small percentage if individuals perform a daily physical exercise for a duration of fewer than 150 minutes
  • Brisk cycling or brisk walking for 150 minutes per week cut development of type ii diabetes (T2D) by 26 percent
  • 60 minute daily moderate or vigorous physical exercise reduces risk to type 2 diabetes (T2D) risk by 40 percent

Researchers analyzed 23 studies from Asia, United States, Australia and Europe and included behavioral factors such as diet and smoking. Lead author of the study is Andrea Smith and co-author of the study is Dr. Soren Brage. The study findings were published in the journal Diabetologia.

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Risks With Low Vitamin B12 During Pregnancy

The previous study shows that during pregnancy, low levels of vitamin B12 likely to result in

  • Increase in body mass index (BMI)
  • Born babies are at risk with low birth weight
  • Born babies are at risk to high cholesterol levels
  • Increased insulin resistance during childhood (and diabetes)
  • Changes in leptin levels

Another previous study shows excess body weight increases leptin levels causing leptin resistance. Leptin resistance causes more food intake, more obesity, more insulin resistance and finally the development of type 2 diabetes (T2D).

Researchers found that newborn babies to mothers with vitamin B12 levels lower than 150 picomoles per liter have higher leptin levels, which is a risk factor to type ii diabetes (T2D) and metabolic disorders. Researchers think that low levels of vitamin B12 in pregnant women may affect leptin gene programming that results in changes in the producer of leptin hormone during fetal development. Babies born to undernourished or overnourished (including low vitamin B12 levels) pregnant women are at increased risk to health problems such as type 2 diabetes (T2D) metabolic disorders.

Now Dr. Ponusammy Saravanan conducting a study on the effects of vitamin B12 on newborn babies. He says

  • Low levels of vitamin B12 may force accumulation of fat in the fetus. Fat accumulation leads to increased leptin hormone levels
  • Low levels of vitamin B12 may result in chemical changes to genes that produce leptin causing more leptin hormone levels

Senior author of the study is Dr. Ponusammy Saravanan and co-author of the study is Dr. Adaikala Antonysunil. The preliminary study findings were presented to Society for Endocrinology annual conference in the U.K.

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B12 : Vitamin B12 helps individuals in a number of body functions and red blood cells production. It is a water-soluble vitamin present in animal products such as eggs, milk, meat, fish etc.

Leptin : Body fat cells produce leptin hormone and also referred as "satiety hormone" or "starvation hormone". The main objective of this hormone is to inform the brain about the stored fat levels in the cells and when to stop eating. It helps in long-term regulation of body energy. Weight abnormality is caused due to body leptin resistance and failure of leptin signaling. Leptin resistance causes more eating and less energy expenditure. Leptin resistance can be reduced by following measures

  • By avoiding processed food
  • Performing the daily physical exercise
  • Sufficient sleep
  • By decreasing triglycerides levels by eating fewer carbohydrates
  • Eating more protein-rich food which causes weight loss and increases leptin sensitivity
  • Eating more soluble fiber



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