Diabetes, Heart and Cardiovascular Diseases News Chronicle Diabetes, Cardiovascular and Heart Diseases. Article 83
Published on November 22, 2016 at 09:30 PM


Statin Usage Reduces Cardiovascular Risk

Previous studies shows that individual with diabetes are at greater risk to cardiovascular disease and usage of statin drugs reduces risk to cardiovascular disease. Researchers analyzed 215,193 diabetes patients and found that just 38 percent of patients are using statin drugs to prevent cardiovascular disease (CVD) and there was 57 percent practice level variation. One guideline suggests diabetes patients between 40 to 75 years with LDL cholesterol possible target of less than 70mg/dL. The American Diabetes Association (ADA) says diabetes patient with over 40 years should take statin therapy irrespective of LDL cholesterol levels and cardiovascular disease (CVD). Senior author of the study is Dr Salim Virani, associate professor at Baylor College of Medicine, Houston and the research letter was published in the Journal of the American College of Cardiology.


       
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Statins : Atheroma patches are small fatty lumps developed within the lining of blood vessels and blocks flow of blood. Blood flow blockage increases risks to heart attack and stroke. Cholesterol is one factor for the development of atheroma. Statins (also known as HMG-CoA reductase inhibitors) are class of drugs to lower lipids such as cholesterol. Studies shows that high cholesterol levels in the blood stream can be reduced in some individuals (about 25 to 35 percent) with the usage of statins class drugs.

Chances of side effects are rare but some of them are

Some of the statin drugs in the market are

Statin therapy is one measure to reduce risk to the development of cardiovascular diseases (CVD). Other measures are

 

Phase 2 Trials of Sotagliflozin Diabetes Drug

Results of phase 2 study on sotagliflozin drug from Lexicon Pharmaceuticals to treat type 1 diabetes (T1D) were positive. Results shows significant decline in blood sugar levels and enhanced drug safety during 12 week study period. Glucose levels in our body was controlled by two proteins, SGLT1 and SGLT2. Sotagliflozin is a oral drug that prevents both proteins. Sotagliflozin drug was joint efforts of Lexicon Pharmaceuticals and Sanofi SA. The phase 2 trials was conducted to select the sotagliflozin drug dosage for the phase 3 trials.


       
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About Gal3 Galectin-3 Protein
A study done by researchers from the University of California-San Diego on obese and diabetic mice shows high levels of macrophages (a type of immune cell) in the fat tissues increases chronic inflammation and insulin resistance in liver, muscle and fat cells. Gal3 or galectin-3 is a signaling protein secreted by macrophages immune cells. The produced galectin-3 protein attracts more macrophages into fat tissues and further increase in galectin-3 protein. Researchers says 40 percent of the cells in overweight individuals (and mice) are of type macrophages. Researchers also observed that blocking Gal3 protein improves insulin sensitivity. Senior author of the study is Prof Jerrold Olefsky. The study was published in the journal Cell.

       
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Diabetes News Chronicle does not provide medical advice, diagnosis or treatment. Information in Diabetes News Chronicle is to support and not to replace medical advice given by surgeon or physician or doctor. Published article is not a medical advice by the OWNER of "Diabetes News Chronicle" website or by the AUTHOR of the article.


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