Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 38
    Published on August 6, 2016


SR10171 Drug For The Treatment Of Bone Disease And Diabetes

In diabetes patients, the risk of bone fracture is two-fold, and some antidiabetic drugs increase the risk further. A proper balance between bone formation (new bone development) and bone turnover (replacing old bone) is missing in diabetes patients. A new drug, referenced as "SR10171", developed at The Scripps Research Institute (TSRI) can be used to treat bone disease and diabetes. The new drug shows increase in the bone mass by bone formation and bone turnover irrespective of BMI index, in normal or obese individual, whether diabetic or non-diabetes patient. The study was done by Prof Patrick R Griffin (The Scripps Research Institute, TSRI) and Prof B Lecka-Czernik (University of Toledo) and the study findings were published in the journal EBioMedicine.



       
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Study Of eGFR Trajectory

Estimated Glomerular Filtration Rate (eGFR) is a test to detect damages to kidneys. The research team led by Dr. Timothy Davis, University of Western Australia analyzed effects of eGFR in 1,296 individuals with type 2 diabetes (T2D). The research findings indicate type 2 diabetes individuals need to monitor Estimated Glomerular Filtration Rate (eGFR) results regularly. Rapid renal decline with high eGFR has increased risk of death in type 2 diabetes (T2D) patients. Study findings were published in the European Journal of Endocrinology.



       
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Risks With High BMI

Swedish Professor Peter Nordstram conducted a study and the study findings indicate higher body mass index (BMI) increases the risk of diabetes but there is no effect on the risk of heart attacks. Experts say a BMI between 18.5 to 24.9 is ideal. Between 25 and 29.9 is categorized as overweight and above 30 is categorized as obese. Researchers examined 4,000 genetically identical twins derived from a single ovum to evaluate risks associated with genetic factors and obesity. The findings indicate that weight loss in an individual will reduce the risk for diabetes more than to cardiovascular disease (CVD) and mortality. The study findings were published in online JAMA Internal Medicine.



       
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Risks To Diabetes Induced Cognitive Impairment

Studies indicate that diabetes increases the risk to age-related cognitive decline (memory, thinking skills etc). Even younger diabetes individuals are showing signs of cognitive decline. A person with mild cognitive impairment (MCI) is at risk of Alzheimer's or dementia.



       
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Risks With Adrenal Tumors NFATs

A retrospective observational study by Dr. Anand Vaidya MD, Harvard Medical School, Boston indicates that there is 2 fold risk of diabetes or prediabetes in persons with non-functional adrenal tumors (NFATs). The study shows that non-functional NFATs may secrete glucocorticoids that increases the risk for metabolic diseases and diabetes. The study findings were published in the journal Annals Of Internal Medicine and the study was funded by National Institutes of Health and the Doris Duke Charitable Foundation.



       
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Risks With Statins Pills

Statins pills are used to lower bad cholesterol levels from the body to protect against heart disease. The study conducted by lead researcher Dr. Michael Holmes, from Oxford University indicates statins pills decreases bad cholesterol from our body but increases the risk of diabetes. Lower levels of low-density lipoprotein (LDL) cholesterol gives low risk to heart diseases with the usage of statins pills but raises the risk to type 2 diabetes (T2D). To avoid diabetes condition, individuals using statins pills should increase good cholesterol. But the guidelines for both the diseases may not change as the benefits from the usage of statins pills are more. The study findings were published in the journal JAMA Cardiology.



       
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Risks To Heart Attack And Diabetes Before Menopause

The findings from the data of around 1,500 women suggest that risks to diabetes, heart disease and stroke accelerates before the onset of menopause in women. The progress is less rapid during postmenopausal period women. Researchers analyzed five important factors (called metabolic syndrome) that may raise the risk of heart disease in women. They are

  • High blood sugar levels
  • High blood fat
  • Low good cholesterol
  • Large waistline
  • High blood pressure (BP)

Researchers say the above five factors (called metabolic syndrome) increases the risk of diabetes and heart diseases. The study findings were published in the Journal of the American Heart Association on Aug 3, 2016.



       
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