Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 31
    Published on July 26, 2016


Study To Treat Diabetic Foot Ulcers

Researchers belonging to School of Dental Medicine (Tufts University) and the Sackler School of Graduate Biomedical Sciences at Tufts, Boston led by Dr. Jonathan Garlick Ph.D., D.D.S found that diabetic foot ulcer skin cells can be reprogrammed to early stages of cell development and may be used to stimulate wound repair and treat chronic wounds. In a second study, the research team found that fibronectin protein is connected to break down in cells and prevent wound healing process in diabetic foot ulcer patients. Previous studies show that fibronectin protein was abnormal in kidney diseases. The study findings were published in the Cellular Reprogramming.



       
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About Abbott LibreLink App

Abbott in partnership with AirStrip released LibreLink mobile App to access FreeStyle Libre sensor glucose data of diabetic patients from Android smartphones. The App displays current blood glucose levels reading, eight-hour blood glucose levels history and current blood glucose levels trend. Diabetes patient can even add a comment or notes to each event scan. The CE Mark LibreLink App can be download from Google Play.



       
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About Maple Syrup Urine Disease (MSUD)

Maple Syrup Urine Disease (MSUD) also known as branched-chain ketoaciduria is a rare inherited metabolic disorder affecting branched-chain amino acids, leucine, isoleucine and valine. MSUD is one type of organic acidemia. Symptoms of the disease include sweet smelling urine and in the sweet smell in ear wax. Infants born with the disease will be healthy at birth but quickly deteriorate and die within weeks. 1 out of 180,000 born babies is affected by this disease. Those diagnosed and treated early may lead a normal life but they must follow controlled and specific diet. Liver transplantation is the only option to treat this disease. Researchers from Buck Institute conducted studies on the effects of metformin drug on skin cells of MSUD patients and mice. Results show that diabetes drug metformin reduces toxic ketoisocaproic acid (KIC) levels associated with MSUD

  • By 20 to 50 percent in cells of MSUD patients
  • By 69 percent in mice

Dr. Arvind Ramanathan PhD is the senior author of the study and the research findings were published in the Scientific Reports.



       
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Study Of Artificial Pancreas

With an artificial pancreas, diabetes patients can control blood sugar levels in an easy, efficient and best way. A study was conducted by University Hospital of Montpellier (France) involving 21 people and the results indicate that good levels of blood sugar can be achieved after wearing the device continuously for a month. The artificial pancreas measures blood glucose levels with a sensor kept beneath the skin. Other components are smartphone software to automate insulin requirement calculations and insulin pump to inject insulin. Manufacturers are planning to start marketing artificial pancreas from 2017. The study findings were published in the journal Diabetes Care.



       
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About Isoprene Chemical Sniffer Dogs

There are reports that dogs are alerting their owners with type 1 diabetes (T1D) whenever their blood glucose levels go low. Researchers from the University of Cambridge believe that naturally occurring chemicals in our breath will change whenever individuals glucose levels drop to a low level, a condition known as hypoglycemia. In a preliminary study to find out unknown chemicals, researchers lowered blood sugar levels in eight women patients with type 1 diabetes (T1D) under controlled conditions and checked the chemical signatures by using mass spectrometry. Researchers found that isoprene chemical level rose significantly during hypoglycemia. Isoprene is a common natural chemical in our breath but we know nothing about it and why its level rises when blood glucose goes to a low level. Researchers suggest that dogs can be trained to sense the isoprene smell and alert their owners about dangerously low blood sugar levels. Researchers are trying to develop detectors to sense elevated levels of isoprene and alert patients with hypoglycemia risk. Research findings were published in the journal Diabetes Care.



       
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