Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 18
    Published on June 17, 2016


Discovery Of TST - TST Protects From high-fat

While studying mice, researchers from universities of Edinburgh and Ljubljana found a gene that protects them from a high-fat diet. The found gene codes to a protein called TST. high-fat cells build up waste products during a high-fat diet. TST protein will detoxify harmful waste build up in the fat cells. Researchers gave a drug that activates TST in a mice model which is obese and suffering from diabetes disease. They found that mice lost weight and severity of diabetes was reduced. Researchers say details of the genes of healthy leanness could lead us to a new approach in treating diabetes associated with obesity. TST levels can be boosted with thiosulfate drug which is used as an antidote for cyanide poisoning and first used 80 years ago. The findings were published in journal Nature Medicine.



       
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Benefits With Cardiovascular Health

The research conducted by Dr. Joshua J Joseph (Johns Hopkins University, Baltimore) examined links between incidents of type 2 diabetes (T2D) and cardiovascular health. They conducted studies among the multi-ethnic population in the US between 2002 to 2012. The study shows that 60% of the diabetes cases attributed to poor cardiovascular health factors. Cardiovascular disease (CVD) and diabetes have common risk factors. They are

  • Physical inactivity
  • Unhealthy dietary habits
  • Obesity

Cardiovascular health can be improved by

  • Proper dietary intake
  • Doing exercise or with physical activity
  • No smoking habits
  • Keeping blood pressure under control
  • Lower cholesterol levels
  • Proper body mass index (BMI)

Mortality rate with CVD is 3 times higher for diabetes patient compared with a non-diabetes patient. The study was published in Diabetologia.



       
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Study For Diabetic Kidney Disease

This study involves examination of DNA samples of diabetes patients to identify genetic factors in developing kidney disease. Diabetes is a leading cause of kidney failure and is often detected at an advanced stage. Five years old study was started at Queens University, Belfast and got grants under US-Ireland Research and Development Partnership Program. The study was conducted by

  • Broad Institute, Boston
  • Queens University
  • University of Helsinki
  • University College Dublin

Professor Peter Maxwell says the project has 3 main goals. They are

  • To find out how some people with diabetes were protected from risks of kidney failure complication by examining important variations in DNA.
  • To find out why a person with diabetes and poor control over blood sugars leads to reprogramming of DNA and increased risk for kidney failure.
  • To develop new test tools to assess the risk of developing kidney complications and to find out best preventive treatment for the kidney failure risk.


       
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Risks To Severe Hypoglycemia

Rozalina McCoy, MD, an endocrinologist at the Mayo Clinic in Rochester have gone through records of 31,542 adults and concluded that risk of severe hypoglycemia will double if the patient undergoes more glucose-lowering medications than recommended to control diabetes mellitus treatment. The findings were published by JAMA Internal Medicine.



       
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Diabetes Link To Stress

A study conducted by Christopher Fagundes and Kyle Murdock of Rice University found a link between emotional stress and diabetes. Brain defaults make some people not able to handle emotional stresses and may lead to anxiety. Diabetes and high blood glucose levels may be activated due to anxiety through the metabolic pathway. The study was published in the Psychoneuroendocrinology.



       
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