Diabetes, Cardiovascular and Heart Diseases  Article 18     Published on June 17, 2016

TST Protein (Gene) That Can Protect Us From A High-Fat Diet

The researchers from the University of Edinburgh and the University of Ljubljana have found a TST gene (a protein) that can protect us from the high-fat diet.

The cells of obese people can build-up the waste products during a high-fat diet. The TST protein can detoxify the build-up of harmful waste in the fat cells.

A study on the obese mice models with diabetes shows the activation of TST gene (or protein) causes a weight loss and a reduced severity of the type 2 diabetes.

Researchers say this study can help in the treatment of type 2 diabetes associated with obesity.

The levels of the TST protein can be boosted with the thiosulfate drug. This drug was used as an antidote for cyanide poisoning. This drug was used for the first time 80 years ago. The study was published in journal Nature Medicine.

       
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Benefits Of Cardiovascular Health

A multi-ethnic population study between 2002 and 2012 at the Johns Hopkins University, Baltimore on the association between type 2 diabetes and cardiovascular diseases show the cause of type 2 diabetes in about 60 percent of the patients with type 2 diabetes is due to the poor management of cardiovascular health.

Both cardiovascular disease (CVD) and diabetes have common risk factors. They are.

• Physically inactive.
• Unhealthy diet.
• Obesity.

Cardiovascular health can be improved by the following measures.

• Healthy diet.
• Regular exercise or physical activity.
• No smoking.
• Blood pressure under control.
• Lower cholesterol levels.
• Lower body mass index (BMI).

The risk of mortality is three times higher in a CVD patient with diabetes when compared with a CVD patient without diabetes. The lead author of the study was Dr. Joshua J Joseph. The study was published in the Diabetologia.

       
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A Study On Diabetic Kidney Disease

Diabetes is a leading cause of kidney failure. The kidney failure is often detected at an advanced stage. A five-year-old study on kidney failure was started at Queens University, Belfast. The study has received grants from the US-Ireland Research and Development Partnership Program. Researchers from the following universities are participating in the study.

• Broad Institute, Boston.
• Queens University.
• The University of Helsinki.
• University College Dublin.

Professor Peter Maxwell says the project has three main goals. They are.

• How some people with diabetes were protected from the risk of kidney failure.
• The cause of reprogramming of the DNA in a poorly managed diabetes patient, leading to an increased risk of kidney failure.
• To develop new testing procedures for the assessment of the risk of kidney failure. To find out the best preventive treatment for kidney failure.

The researchers are planning to identify the genetic factors for the risk of kidney disease by studying the DNA samples of patients with diabetes.

       
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Risk To Severe Hypoglycemia

Dr. Rozalina McCoy, MD, an endocrinologist at the Mayo Clinic at Rochester have gone through the records of 31,542 adults and found a double risk of severe hypoglycemia in the patients taking increased treatments (or drugs) to lower the blood sugar (glucose) levels than recommended. The study was published in the JAMA Internal Medicine.

       
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Diabetes Link To Stress

A study by Christopher Fagundes and Kyle Murdock at Rice University has found a link between emotional stress and diabetes. The study shows the brain of some people can not handle the emotional stress and cause anxiety. The anxiety will increase the blood sugar (glucose) levels through the metabolic pathway. The study was published in the Psychoneuroendocrinology.

       
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