A study by researchers from the UK shows repairing of damaged heart tissue with stem cells to prevent heart failure. Initial trial results of the current trial show reversing of scarring by 79 percent and an average 40 percent reduction in heart damage with engineered stem cells known as Heartcel. A high-level meeting paved a way for the researchers to conduct initial trials at two London hospitals with more than 100 patients during autumn. The researchers finalized global trials involving 500 people after discussing with the United States and European regulators.
This technique could end the heart transplant procedures and can lead to heart failure treatment procedure in coming years. Professor Steve Westaby, a cardiac surgeon from John Radcliffe Hospital, Oxford was carrying out the study along with Professor Kim Fox, head of the National Heart and Lung Institute, Imperial College London. The study findings were presented in the European Society of Cell and Gene Therapy, Florence.
Infective endocarditis is a heart disease caused due to bacteria. The researchers from the University of Bristol, England have identified the molecular process that moves mouth bacteria through the bloodstream to cause infective endocarditis. Previous studies show the formation of blood clots in heart valves due to the bacteria. Mortality rate with blood clots in heart valves is 30 percent. If left untreated, sometimes the result is fatal.
The researchers identified the structure and dynamics of the CshA protein that acts as a "molecular lasso" to enable streptococcus gordonii mouth bacteria to bind to the surface of the human cells. Binding streptococcus gordonii mouth bacteria to human cells is the first step in causing disease. Researchers named this mechanism as "catch-clamp" mechanism. The researchers say development of anti-adhesive agents targeting disease-causing streptococcus gordonii mouth bacteria to prevent them from binding to human cells to treat the disease. Lead author of the study is Dr. Catherine Back and co-author of the study is Dr. Angela Nobbs from School of Oral and Dental Sciences, Bristol University and the study findings were published in the Journal of Biological Chemistry.
Infective endocarditis : The inner tissue of the heart valves is called endocardium. Inflammation of the endocardium is known as infective endocarditis. Inflammation will be caused due to infectious agents and fungi. This may result in the growth of bacteria on the valves of the heart. Symptoms of inflammation include weakness, discomfort, shortness of breath and fever
A study by researchers from the University of Florida, the United States and Erasmus Medical Center, Netherlands shows a successful delay in the development of diabetic retinopathy in rat models with a combination of two drugs. The combination therapy is known as angiotensin receptor neprilysin inhibitor (ARNI). This therapy includes a blood pressure drug (irbesartan) and diarrhoea (or diarrhea) drug (thiorphan). This study was done on rat models for 12 weeks.
The innovative combination therapy can slowdown the development of retinopathy but it can not treat damages already caused by retinopathy. The researchers say more studies has to be done to find out possible side effects with the combination treatment before starting human trials. Co-author of the study is Dr. Tuhina Prasad, a postdoctoral associate, College of Medicine, University of Florida and the study findings were published in the Investigative Ophthalmology and Visual Science journal.
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Published by Jammi Vasista, Chennai, India.