Diabetes, Heart and Cardiovascular Diseases News Chronicle.  Diabetes, Cardiovascular and Heart Diseases
 Article 13
    Published on June 13, 2016


Trials With FGF1 Hormone

Researchers found direct-to-the-brain treatment for type 2 diabetes (T2D) by injecting a single dose of hormone Fibroblast Growth Factor 1 (FGF1) into the brain via the intra-nasal route. The mice experienced lasting relief (17 weeks) from type 2 diabetes (T2D) without a change in its diet or weight. This 17 weeks of mice life is equivalent to 12 years for a human. This relief is not dependent on weight loss, diet changes or exercises. Researchers believe the brain can control blood glucose levels after injecting hormone FGF1. This type of remission seen only in bariatric surgery. There is a wide range of medications available but almost all require substantial weight loss for the success of the treatment. This experiment unlikely to initiate similar approaches to humans but scientists says intranasal delivery of FGF1 to the brain is possible. The study was led by Michael W. Schwartz (endocrinologist), Jarrad M. Scarlett (gastroenterologist) and Jennifer M. Rojas (molecular physiologist). The findings were published in the Nature Medicine.



       
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Risks To Postmenopausal Women

Atherosclerotic cardiovascular disease risk was increased in newly diagnosed postmenopausal diabetes women, even if they take statin drugs. In general, atherosclerotic cardiovascular disease events will decrease with statin therapy. Those events are

But statin therapy increases diabetes risk but researchers hypothesized the risk will be milder to atherosclerotic cardiovascular disease. The study results show it is important for post-menopausal women to prevent, monitor and detect diabetes, even if they are taking statin medication. Researchers belonging to the UMass Medical School. Prof Yunsheng Ma is the author of the study and JoAnn E Manson is the co-author of the study. The above findings were published in the European Journal of Epidemiology.



       
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Risks With Poor Lifestyle

Gestational diabetes (GD) leads to type 2 diabetes (T2D) due to our genes. Our genes behavior changes due to a change in proteins (histones) within our cells. Change in histones happens because of poor lifestyle. During 2 years of study, researchers measured histones proteins of 4 women groups during pregnancy and postpartum. They are

  • A group with no diabetes
  • A group with type 2 diabetes (T2D) before pregnancy
  • A group with gestational diabetes + having type 2 diabetes (T2D) after pregnancy
  • A group with gestational diabetes + no type 2 diabetes (T2D) after pregnancy

Researchers found that different type of histones between women who developed type 2 diabetes (T2D) after gestational diabetes and women without type 2 diabetes (T2D). The histones were different between each group. Prof Leigh says with this study, medical professionals can predict the development of type 2 diabetes (T2D) in gestational diabetes patients. The research was done by Prof Leigh Ackland, the Deakin University. The findings were published in the Journal of Clinical Endocrinology and Metabolism.



       
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Benefits With Fruit Compounds

A study conducted by Paul Thornalley, a Prof at Warwick suggested red grapes and oranges (taken together) offers a new treatment for obesity, diabetes and cardiovascular disease (CVD). It was found to be more effective than metformin drug. Methylglyoxal (MG) is the key driver for the harmful effects of sugar in the body. High levels of MG and high-calorie diet is the cause of the insulin resistance. MG damages blood vessels and increases cholesterol levels too (risk for CVD). Researchers found that red grapes contain trans-resveratrol (tRES) and oranges contain hesperetin (HESP). Red grapes and oranges combination increases Glo1. Glo1 is an enzyme that neutralizes the compound Methylglyoxal (MG). The study received funding from the UK's innovation agency, Innovate UK. The findings were published in the journal Diabetes.



       
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