Diabetes, Heart and Cardiovascular Diseases News Chronicle Diabetes, Cardiovascular and Heart Diseases. Article 13
Published on June 13, 2016 at 9:05 AM


Trials With FGF1 Hormone

Researchers found direct-to-the-brain treatment for type 2 diabetes (T2D) by injecting single dose of hormone Fibroblast Growth Factor 1 (FGF1) into brain via the intra-nasal route. The mice experienced lasting relief (17 weeks) from type ii diabetes (T2D) without change in its diet or weight. This 17 weeks of mice life is equivalent to 12 years for human. This relief is not dependent on weight loss, diet changes or exercises. Researchers believe brain can control blood glucose levels after injecting hormone FGF1. This type of remission seen only in bariatric surgery. There are wide range of medications available but almost all require substantial weight loss for the success of the treatment. This experiment unlikely to initiate similar approaches to humans but scientists says intranasal delivery of FGF1 to the brain is possible. The study was led by Michael W. Schwartz (endocrinologist), Jarrad M. Scarlett (gastroenterologist) and Jennifer M. Rojas (molecular physiologist). The findings were published in the Nature Medicine.

       
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Risks To Postmenopausal Women

Atherosclerotic cardiovascular disease risk was increased in newly diagnosed postmenopausal diabetes women, even if they take statin drugs. In general, atherosclerotic cardiovascular disease events will decreases with statin therapy. Those events are

But statin therapy increases diabetes risk but researchers hypothesized the risk will be milder to atherosclerotic cardiovascular disease. The study results shows it is important for post-menopausal women to prevent, monitor and detect diabetes, even if they are taking statin medication. Researchers belong to UMass Medical School. Prof Yunsheng Ma is the author of the study and JoAnn E Manson is the co-author of the study. The above findings were published in the European Journal of Epidemiology.

       
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Risks With Poor Lifestyle

Gestational diabetes (GD) leads to type 2 diabetes (T2D) due to our genes. Our genes behavior changes due to change in proteins (histones) within our cells. Change in histones happen because of poor lifestyle. During 2 years study, researchers measured histones proteins of 4 women groups during pregnancy and postpartum. They are

Researchers found that different type of histones between women who developed type 2 diabetes (T2D) after gestational diabetes and women without type 2 diabetes (T2D). The histones were different between each group. Prof Leigh says with this study, medical professionals can predict development of type 2 diabetes (T2D) in gestational diabetes patients. Research was done by Prof Leigh Ackland, Deakin University. The findings were published in the Journal of Clinical Endocrinology and Metabolism.

       
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Benefits With Fruit Compounds

A study conducted by Paul Thornalley, a Prof at Warwick suggested red grapes and oranges (taken together) offers new treatment for obesity, diabetes and cardiovascular disease (CVD). It was found to be more effective than metformin drug. Methylglyoxal (MG) is the key driver for the harmful effects of sugar in the body. High levels of MG and high calorie diet is the cause of the insulin resistance. MG damages blood vessels and increase cholesterol levels too (risk for CVD). Researchers found that red grapes contains trans-resveratrol (tRES) and oranges contains hesperetin (HESP). Red grapes and oranges combination increases Glo1. Glo1 is an enzyme that neutralizes the compound Methylglyoxal (MG). The study received funding from the UK's innovation agency, Innovate UK. The findings were published in the journal Diabetes.

       
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